Pharmacokinetics
Pharmacokinetic calculations relate dose to concentration through volume of distribution, clearance, and half-life. The linked workspace takes any sufficient subset of those parameters and derives the rest, labelling each result with the relation used to obtain it rather than returning bare numbers. Alongside it sit absolute bioavailability from AUC and dose, prediction of a future or past concentration from a measured one, and the loading dose required to reach a target concentration without waiting the five half-lives that maintenance dosing alone would take.
Pharmacokinetic workspace (linked solver)
Enter any sufficient subset of pharmacokinetic parameters and derive the rest, with each result labelled by the relation used to obtain it.
Absolute bioavailability (F)
Calculate absolute bioavailability from the areas under the curve and doses of an extravascular and an intravenous administration.
Predicting drug concentrations
Predict a future concentration from a measured one, calculate the elimination rate constant from two measured concentrations, or find the time needed to reach a target concentration.
Loading dose High-risk
Calculate the dose needed to reach a target plasma concentration immediately, rather than waiting the five half-lives that maintenance dosing alone would require.
High-consequence calculations in this group
These carry a greater risk of harm if the result is wrong or misapplied. Each states its own limits on its page; read them before acting on a number.
- Loading dose — Calculate the dose needed to reach a target plasma concentration immediately, rather than waiting the five half-lives that maintenance dosing alone would require.
Where to go next
- Guides — longer explanations of how to work through a calculation and how to choose between related calculators.
- Practice problems — one worked problem for every calculator, solutions hidden until you open them.
- Reference tables and formula sheet — every constant and conversion factor used here, with citations.
- All 58 calculators — the full index, filterable by category.
Other categories
Also known as
pharmacokinetics · Vd · clearance · ke · half life · AUC · PK · elimination rate constant · bioavailability · F · absolute bioavailability · first pass · C2 · concentration prediction · elimination · first order · decay · when will level fall · loading dose · LD · bolus · digoxin loading · phenytoin loading